Three types of problems are raised in this commentary: On the linguistic side, we emphasize the importance of an appropriate definition of the different domains of linguistics. This is needed to define the domains (lexicon-syntax-semantics) to which transformational relations apply. We then question the concept of Broca's aphasia as a “functional” syndrome, associated with a specific lesion. Finally, we discuss evidence from functional brain imaging. The breadth and potential impact of such evidence has grown considerably in the last few years, (...) expanding our knowledge of the multiple contributions of the “Broca's region” to phonological, lexical-semantic, and syntactic processing. “Lumping” under diagnostic labels, such as Broca's aphasia, should be replaced by more detailed linguistic and neurological descriptions of the clinical cases. (shrink)

The evidence about asymmetries between the two hemispheres in human and non-human species may contribute to the current debate about language evolution. Here I present a selective review of the available data, limited to the macroscopic and microscopic anatomy of the main language areas. Both post-mortem and imaging studies confirm the presence of a leftward asymmetry in the Planum Temporale region in humans; in the case of Broca’s area the evidence is less consistent. The data about non-human primates also support (...) the presence of a leftward asymmetry of the PT area in apes and monkeys. Studies on large populations, combining quantitative structural imaging of cortex and white matter, functional imaging measures during language tasks, and detailed assessments of handedness are needed to assess the relevance of comparative brain anatomy data to the investigation of language evolution. (shrink)

The COVID-19 pandemic is a health issue leading older adults to an increased vulnerability to unfavorable outcomes. Indeed, the presence of physical frailty has recently led to higher mortality due to SARS-CoV-2 infection. However, no longitudinal studies have investigated the role of neuropsychogeriatric factors associated with lockdown fatigue in healthy cognitive aging. Eighty-one healthy older adults were evaluated for their neuropsychological characteristics, including physical frailty, before the pandemic. Subsequently, 50 of them agreed to be interviewed and neuropsychologically re-assessed during the (...) lockdown and immediately after it. Moreover, during another home confinement, they performed a psychological screening to evaluate possible mood changes and fatigue. According to Fried's frailty criteria, at T0, 63% of the sample was robust, 34.5% pre-frail, and only 2.5% frail. Significantly, these subjects presented a decrease in handgrip strength and walking speed. Results from Principal Component Analyses and multiple regression models highlighted the contribution of “cognitive” and “psychological” factors in explaining handgrip strength and gait speed. At T3, lockdown fatigue was explained by higher scores on the Beck Depression Inventory and lower scores on the Trail Making Test part A. Results from a moderated-mediation model showed that the effect of psychomotor speed on lockdown fatigue was mediated by depression, with a moderating effect of gait speed. Our findings highlight the complex interrelationship between cognitive, psychological, and physical factors in the emergence of pandemic fatigue in a carefully selected older population. (shrink)

v. 1. Irrat͡sionalizm v nemet͡skoĭ filosofii XIX veka -- v. 2. Navstrechu Logosu : problema poznanii͡a v ėkzistent͡sializme i germenevtike.